IL-12-expressing mesenchymal stem cell vaccine GX-051

{
  "id": "MLC-T-ONC-014348",
  "term": "IL-12-expressing mesenchymal stem cell vaccine GX-051",
  "field": "Oncology and biomedicine",
  "definition": "Human mesenchymal stem cells (MSCs) transduced with a retroviral vector encoding a modified form of the cytokine interleukin-12 (IL-12), with potential immunomodulating and antineoplastic activities. Upon intratumoral administration, IL-12-expressing MSC vaccine GX-051 secretes IL-12. IL-12 activates the immune system by both promoting the secretion of interferon-gamma, which activates natural killer cells (NKs), and inducing cytotoxic T-cell responses, which may result in both decreased cell proliferation and increased cell death in tumor cells.",
  "abbreviation": "MSCs/IL-12M",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/il-12-expressing-mesenchymal-stem-cell-vaccine-gx-051/"
}