autologous mRNA-encoding NSCLC neoantigens dendritic cell vaccine

{
  "id": "MLC-T-ONC-011702",
  "term": "autologous mRNA-encoding NSCLC neoantigens dendritic cell vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A dendritic cell (DC) - based cancer vaccine in which the autologous, in vitro activated DCs are loaded with messenger RNA (mRNA) encoding neoantigens from the patient’s non-small cell lung cancer (NSCLC), with potential immunomodulating and antineoplastic activities. Upon administration of autologous mRNA-encoding NSCLC neoantigens DC vaccine, the mRNA gets expressed into neoantigens in cells and the neoantgens activate the immune system to induce robust neoantigen-specific T-cell responses against the NSCLCs expressing these neoantigens. The neoantigens are predicted from the patient-individual tumor's mutanome.",
  "synonyms": [
    "autologous mRNA-loaded NSCLC DC vaccine",
    "MIDRIXNEO-LUNG autologous DC vaccine",
    "autologous MIDRIXNEO-LUNG dendritic cell vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-mrna-encoding-nsclc-neoantigens-dendritic-cell-vaccine/"
}