Autologous NSCLC DNA-transfected semi-allogeneic fibroblasts MRC-5 vaccine

{
  "id": "MLC-T-ONC-011721",
  "term": "Autologous NSCLC DNA-transfected semi-allogeneic fibroblasts MRC-5 vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A vaccine consisting of irradiated human fetal lung fibroblasts (Medical Research Council 5 or MRC-5) transfected with autologous non-small cell lung cancer (NSCLC)-derived DNA with potential immunostimulatory and antineoplastic activities. Upon administration, autologous NSCLC DNA-transfected semi-allogeneic fibroblasts MRC-5 vaccine expresses NSCLC tumor-associated antigens (TAAs) in addition to MHC class I-determinants and the co-stimulatory molecule B7.1, which may induce a cytotoxic T-lymphocyte (CTL) response against NSCLC cells. The MRC-5 cell line is a human diploid lung fibroblast cell line extablished in 1966.",
  "synonyms": [
    "autologous non-small cell lung cancer DNA-transfected semi-allogeneic fibroblasts MRC-5 vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-nsclc-dna-transfected-semi-allogeneic-fibroblasts-mrc-5-vaccine/"
}