Autologous HNSCC DNA-transfected semi-allogeneic fibroblasts MRC-5 vaccine

{
  "id": "MLC-T-ONC-011649",
  "term": "Autologous HNSCC DNA-transfected semi-allogeneic fibroblasts MRC-5 vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A vaccine consisting of lethally irradiated human fetal lung fibroblasts (Medical Research Council 5 or MRC-5) transfected with autologous tumor DNA derived from a head and neck squamous cell carcinoma (HNSCC), with potential immunostimulatory and antineoplastic activities. Upon intradermal administration, the autologous HNSCC DNA-transfected semi-allogeneic fibroblasts MRC-5 vaccine expresses HNSCC tumor-associated antigens (TAAs), which may activate the immune system to induce a cytotoxic T-lymphocyte (CTL) response against HNSCC cells. The MRC-5 cell line, established in 1966, is a human diploid lung fibroblast cell line derived from the human lung tissue of a 14-week-old male fetus.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-hnscc-dna-transfected-semi-allogeneic-fibroblasts-mrc-5-vaccine/"
}