allogeneic GM-CSF-secreting lethally irradiated whole melanoma cell vaccine

{
  "id": "MLC-T-ONC-009896",
  "term": "allogeneic GM-CSF-secreting lethally irradiated whole melanoma cell vaccine",
  "field": "Oncology and biomedicine",
  "definition": "An allogeneic cancer vaccine composed of lethally irradiated whole melanoma cancer cells that are genetically modified to secrete the immunostimulatory cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF), with potential immunostimulating and antineoplastic activities. Upon intradermal injections, allogeneic GM-CSF-secreting lethally irradiated whole melanoma cell vaccine secretes GM-CSF. In turn, GM-CSF may stimulate the body's immune system against tumor cells by enhancing the activation of dendritic cells (DCs) and promoting antigen presentation to both B- and T-lymphocytes. In addition, GM-CSF promotes antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin-2-mediated lymphokine-activated killer cell function.",
  "synonyms": [
    "GVAX melanoma vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-gm-csf-secreting-lethally-irradiated-whole-melanoma-cell-vaccine/"
}