Allogeneic GM-CSF-secreting breast cancer vaccine SV-BR-1-GM

{
  "id": "MLC-T-ONC-009893",
  "term": "Allogeneic GM-CSF-secreting breast cancer vaccine SV-BR-1-GM",
  "field": "Oncology and biomedicine",
  "definition": "A vaccine consisting of irradiated allogeneic breast cancer cells, derived from the breast cancer cell line SV-BR-1 that are transfected with the immunostimulant granulocyte-macrophage colony-stimulating factor (GM-CSF; CSF2) gene, with potential immunostimulating and antineoplastic activities. Upon intradermal administration of the allogeneic GM-CSF-secreting breast cancer vaccine SV-BR-1-GM, the genetically-modified cells secrete GM-CSF. This potentiates a tumor-specific cytotoxic T-lymphocyte (CTL) immune response against breast cancer cells.",
  "synonyms": [
    "SV-BR-1-GM",
    "SV-BR-1 breast cancer cell line vaccine",
    "SV-BR-1-GM vaccine",
    "GM-CSF gene-transfected breast cancer vaccine SV-BR-1-GM",
    "Breast Cancer Vaccine SV-BR-1-GM"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-gm-csf-secreting-breast-cancer-vaccine-sv-br-1-gm/"
}