allogeneic GM-CSF-secreting lethally irradiated prostate cancer vaccine

{
  "id": "MLC-T-ONC-009895",
  "term": "allogeneic GM-CSF-secreting lethally irradiated prostate cancer vaccine",
  "field": "Oncology and biomedicine",
  "definition": "An allogeneic whole cell vaccine expressing human granulocyte macrophage-colony stimulating factor (GM-CSF) with potential antineoplastic activity. Tumor cells from prostate cancer patients are harvested and then genetically modified to secrete GM-CSF, an immune stimulatory growth factor that plays a key role in stimulating the body's immune responses against tumor cells. Because the vaccine is derived from allogenic cells, it has demonstrated a favorable side effect profile than other approaches of delivering long-lasting GM-CSF.",
  "synonyms": [
    "GVAX prostate",
    "GM-CSF gene transduced allogeneic prostate cancer vaccine",
    "GM-CSF prostate cancer vaccine",
    "allogeneic prostate cancer vaccine, GM-CSF gene transduced",
    "prostate cancer vaccine, GM-CSF gene transduced",
    "allogeneic prostate GVAX",
    "GVAX allogeneic prostate cancer vaccine",
    "allogeneic GM-CSF prostate cancer vaccine",
    "allogeneic prostate cancer vaccine, GM- CSF gene transduced",
    "allogenic prostate GVAX",
    "GVAX allogenic prostate cancer vaccine",
    "GVAX prostate cancer vaccine",
    "prostate cancer vaccine, GVAX"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-gm-csf-secreting-lethally-irradiated-prostate-cancer-vaccine/"
}