Allogeneic GM-CSF-secreting lethally irradiated pancreatic tumor cell vaccine

{
  "id": "MLC-T-ONC-009894",
  "term": "Allogeneic GM-CSF-secreting lethally irradiated pancreatic tumor cell vaccine",
  "field": "Oncology and biomedicine",
  "definition": "An allogeneic tumor vaccine composed of lethally irradiated allogeneic pancreatic tumor cells that are genetically modified to secrete the immunostimulatory cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF), with potential immunostimulating and antineoplastic activities. Upon intradermal injection, allogeneic GM-CSF-secreting lethally irradiated pancreatic tumor cell vaccine secretes GM-CSF at the injection site. In turn, GM-CSF may stimulate the body's immune system against tumor cells by attracting and enhancing the activation of antigen-presenting cells (APCs), such as dendritic cells (DCs). This promotes antigen presentation to T lymphocytes and induces a cytotoxic T-lymphocyte (CTL) response against the pancreatic tumor cells expressing the pancreatic tumor-associated antigens (TAAs).",
  "synonyms": [
    "GVAX allogeneic irradiated pancreatic tumor cell vaccine",
    "irradiated allogeneic GM-CSF-secreting pancreatic tumor cell vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-gm-csf-secreting-lethally-irradiated-pancreatic-tumor-cell-vaccine/"
}