autologous GM-CSF-secreting breast cancer vaccine

{
  "id": "MLC-T-ONC-011635",
  "term": "autologous GM-CSF-secreting breast cancer vaccine",
  "field": "Oncology and biomedicine",
  "definition": "An autologous tumor cell vaccine containing irradiated breast cancer cells transfected with the granulocyte macrophage-colony-stimulating factor (GM-CSF) gene with potential antineoplastic activity. Autologous breast cancer cells are transduced ex vivo with an adenovirus vector encoding the GM-CSF gene and irradiated and then reintroduced into the patient. Upon repeated subcutaneous administration of the vaccine, autologous GM-CSF-secreting breast cancer cells secrete GM-CSF, which may stimulate a tumor-specific cytotoxic T-lymphocyte (CTL) response.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-gm-csf-secreting-breast-cancer-vaccine/"
}