Hodgkin's antigens-GM-CSF-expressing cell vaccine

{
  "id": "MLC-T-ONC-014157",
  "term": "Hodgkin's antigens-GM-CSF-expressing cell vaccine",
  "field": "Oncology and biomedicine",
  "definition": "An allogeneic vaccine consisting of Hodgkin lymphoma cells transfected with the granulocyte macrophage-colony-stimulating factor (GM-CSF) gene with potential antineoplastic activity. Upon vaccination, Hodgkin antigens-GM-CSF-expressing cell vaccine may stimulate a cytotoxic T-lymphocyte (CTL) immune response against Hodgkin lymphoma-associated antigens, which may result in the lysis of tumor cells expressing these antigens. In addition, transfected Hodgkin lymphopma cells secrete GM-CSF, which may potentiate the CTL response against Hodgkin lymphoma-associated antigens.",
  "synonyms": [
    "Hodgkin antigens-GM-CSF-expressing cell vaccine",
    "KGEL vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/hodgkin-s-antigens-gm-csf-expressing-cell-vaccine/"
}