Autologous GM-CSF-secreting lethally irradiated pancreatic cancer vaccine

{
  "id": "MLC-T-ONC-011639",
  "term": "Autologous GM-CSF-secreting lethally irradiated pancreatic cancer vaccine",
  "field": "Oncology and biomedicine",
  "definition": "An irradiated, autologous pancreatic cancer vaccine consisting of patient-specific pancreatic cancer cells genetically modified to secrete the cytokine granulocyte-macrophage colony stimulating factor (GM-CSF), with potential immunostimulating and antineoplastic activities. Upon vaccination, GVAX pancreatic cancer vaccine secretes GM-CSF. In turn, GM-CSF may stimulate the body's immune system against tumor cells by enhancing the activation of dendritic cells (DCs) and promoting antigen presentation to both B and T cells. In addition, GM-CSF promotes antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin-2-mediated lymphokine-activated killer cell function.",
  "synonyms": [
    "GM-CSF gene transduced autologous pancreatic cancer vaccine",
    "autologous GVAX pancreatic cancer vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-gm-csf-secreting-lethally-irradiated-pancreatic-cancer-vaccine/"
}