ovapuldencel-T

{
  "id": "MLC-T-ONC-015722",
  "term": "ovapuldencel-T",
  "field": "Oncology and biomedicine",
  "definition": "A cancer vaccine consisting of autologous dendritic cells (DCs) loaded with autologous, lethally irradiated cancer cells and mixed with the cytokine granulocyte-macrophage colony stimulating factor (GM-CSF), with potential immunostimulatory and antineoplastic activities. Upon vaccination, ovapuldencel-T may stimulate the immune system to exert a cytotoxic T-lymphocyte (CTL) immune response against the repertoire of tumor associated antigens (TAAs) found in the irradiated cancer cells. GM-CSF enhances the activation of dendritic cells (DCs) and promotes antigen presentation to both B- and T-lymphocytes.",
  "synonyms": [
    "autologous dendritic cells loaded with irradiated autologous tumor cells in GM-CSF"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/ovapuldencel-t/"
}