eltrapuldencel-T

{
  "id": "MLC-T-ONC-013315",
  "term": "eltrapuldencel-T",
  "field": "Oncology and biomedicine",
  "definition": "A therapeutic melanoma vaccine consisting of autologous dendritic cells (DCs) pulsed with antigens from lethally irradiated autologous tumor cells derived from a patient-specific, continuously proliferating and melanoma-initiating cell line and suspended in a solution containing the cytokine granulocyte-macrophage colony stimulating factor (GM-CSF), with potential immunostimulatory and antineoplastic activities. Upon subcutaneous administration, eltrapuldencel-T may stimulate the immune system to exert a cytotoxic T-lymphocyte (CTL) immune response against the patient's repertoire of melanoma-associated antigens, particularly tumor stem cell antigens, found in the irradiated autologous cancer cells. As an immunostimulant, GM-CSF enhances the activation of dendritic cells (DCs) and promotes antigen presentation to both B and T lymphocytes.",
  "abbreviation": "DC-TC",
  "synonyms": [
    "autologous DCs loaded with irradiated autologous tumor cells in GM-CSF",
    "autologous dendritic cells loaded with irradiated autologous tumor cells in granulocyte-macrophage colony-stimulating factor",
    "melapuldencel-T"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/eltrapuldencel-t/"
}