Autologous GM-CSF-secreting lethally irradiated colorectal cancer cell vaccine

{
  "id": "MLC-T-ONC-011636",
  "term": "Autologous GM-CSF-secreting lethally irradiated colorectal cancer cell vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A lethally irradiated, autologous colorectal cancer vaccine consisting of patient-specific colorectal cancer cells genetically modified to secrete the cytokine granulocyte-macrophage colony stimulating factor (GM-CSF), with potential immunostimulating and antineoplastic activities. Upon vaccination, the autologous GM-CSF-secreting lethally irradiated colorectal cancer cell vaccine releases GM-CSF. In turn, GM-CSF may increase the body's immune response against tumor cells by promoting the maturation and activation of dendritic cells (DCs), and enhancing tumor-specific antigen presentation to both B- and T-cells, which leads to better recognition of tumors by the immune system. In addition, GM-CSF promotes antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin-2-mediated lymphokine-activated killer cell function.",
  "synonyms": [
    "GVAX colorectal cancer vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-gm-csf-secreting-lethally-irradiated-colorectal-cancer-cell-vaccine/"
}