autologous GM-CSF-secreting lethally irradiated leukemia cell vaccine

{
  "id": "MLC-T-ONC-011637",
  "term": "autologous GM-CSF-secreting lethally irradiated leukemia cell vaccine",
  "field": "Oncology and biomedicine",
  "definition": "An autologous cancer vaccine composed of lethally irradiated leukemia cells that are genetically modified to secrete the immunostimulatory cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF), with potential immunostimulating and antineoplastic activities. Upon intradermal injection, the autologous GM-CSF-secreting lethally irradiated leukemia cell vaccine secretes GM-CSF. In turn, GM-CSF may stimulate the immune system to attack tumor cells by enhancing the activation of dendritic cells (DCs) and promoting antigen presentation to both B and T lymphocytes. In addition, GM-CSF promotes antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin-2-mediated lymphokine-activated killer cell function.",
  "synonyms": [
    "autologous GVAX leukemia vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-gm-csf-secreting-lethally-irradiated-leukemia-cell-vaccine/"
}