Autologous GM-CSF-secreting lethally irradiated lung cancer vaccine

{
  "id": "MLC-T-ONC-011638",
  "term": "Autologous GM-CSF-secreting lethally irradiated lung cancer vaccine",
  "field": "Oncology and biomedicine",
  "definition": "An autologous lung cancer vaccine consisting of patient-specific lung cancer cells genetically modified to secrete granulocyte-macrophage colony stimulating factor (GM-CSF), an immunostimulatory cytokine. GM-CSF modulates the proliferation and differentiation of a variety of hematopoietic progenitor cells with some specificity towards stimulation of leukocyte production and may reverse treatment-induced neutropenias. This agent also promotes antigen presentation, up-regulates antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin-2-mediated lymphokine-activated killer cell function and may augment host antitumoral immunity. For safety, cells are irradiated prior to vaccination.",
  "synonyms": [
    "autologous GVAX lung cancer vaccine",
    "GVAX autologous lung cancer vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-gm-csf-secreting-lethally-irradiated-lung-cancer-vaccine/"
}