Sargramostim

{
  "id": "MLC-T-ONC-007557",
  "term": "Sargramostim",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance that helps make more white blood cells, especially granulocytes, macrophages, and cells that become platelets. It is a cytokine that is a type of hematopoietic (blood-forming) agent. Also called GM-CSF and granulocyte-macrophage colony-stimulating factor.",
    "A recombinant therapeutic agent which is chemically identical to or similar to endogenous human GM-CSF. Binding to specific cell surface receptors, sargramostim modulates the proliferation and differentiation of a variety of hematopoietic progenitor cells with some specificity towards stimulation of leukocyte production and may reverse treatment-induced neutropenias. This agent also promotes antigen presentation, up-regulates antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin-2-mediated lymphokine-activated killer cell function; it may also augment host antitumoral immunity."
  ],
  "abbreviation": "GM CSF",
  "synonyms": [
    "GM-CSF",
    "granulocyte-macrophage colony-stimulating factor",
    "granulocyte macrophage colony-stimulating factor",
    "23-L-leucine colony-stimulating factor 2",
    "sargramostatin",
    "CSF-2",
    "colony stimulating factor 2"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/sargramostim/"
}