Molgramostim

{
  "id": "MLC-T-ONC-015236",
  "term": "Molgramostim",
  "field": "Oncology and biomedicine",
  "definition": "A recombinant form of human granulocyte macrophage colony stimulating factor (GM-CSF), with potential immunostimulating activity. Upon administration as inhalation solution via nebulizer, molgramostim binds to specific cell surface receptors and promotes or restores GM-CSF signaling, thereby modulating the proliferation and differentiation of a variety of hematopoietic progenitor cells with some specificity towards stimulation of leukocyte production. This agent also activates neutrophils, monocytes, macrophages, and dendritic cells and promotes antigen presentation, upregulates antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin (IL)-2-mediated, lymphokine-activated killer cell function. In addition, the restoration of GM-CSF signaling promotes surfactant clearing by pulmonary alveolar macrophages.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/molgramostim/"
}