sargramostim plasmid DNA pancreatic tumor cell vaccine

{
  "id": "MLC-T-ONC-016646",
  "term": "sargramostim plasmid DNA pancreatic tumor cell vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A whole cell vaccine comprised of irradiated allogenic pancreatic tumor cells transfected with a plasmid DNA encoding human sargramostim (GM-CSF). Vaccination results in expression of GM-CSF, which induces proliferation and differentiation hematopoietic lineage cells as well as stimulating macrophage and dendritic cell functions in antigen presentation and antitumor cell-mediated immunity. Furthermore, administration of this pancreatic tumor cell vaccine may elicit a cytotoxic T lymphocyte (CTL) response against similar host tumor cells, resulting in decreased tumor growth.",
  "synonyms": [
    "GM-CSF plasmid DNA pancreatic tumor cell vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/sargramostim-plasmid-dna-pancreatic-tumor-cell-vaccine/"
}