Irradiated allogeneic human lung cancer cells expressing OX40L-Ig vaccine HS-130

{
  "id": "MLC-T-ONC-014582",
  "term": "Irradiated allogeneic human lung cancer cells expressing OX40L-Ig vaccine HS-130",
  "field": "Oncology and biomedicine",
  "definition": "An allogeneic irradiated human lung cancer cell vaccine expressing a fusion protein composed of the OX40 ligand (OX40L) linked to an immunoglobulin (Ig) (OX40L-Ig), with potential immunomodulating and antineoplastic activities. Upon intradermal administration of irradiated allogeneic human lung cancer cells expressing OX40L-Ig vaccine HS-130, the irradiated lung cancer cells continuously express OX40L-Ig. OX40L may then target, bind to and activate its cognate receptor, tumor necrosis factor receptor superfamily member 4 (TNFRSF4; OX40; CD134), which is expressed on activated T cells. OX40L/OX40 binding promotes increased cytokine production, and induces the proliferation and activation of memory and effector T lymphocytes against the human lung cancer cells. In turn, this promotes a CTL-mediated immune response against the endogenous lung cancer cells. OX40L, a cell surface glycoprotein and member of the tumor necrosis factor (TNF) ligand family, provides a co-stimulatory signal for the proliferation and survival of activated T cells.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/irradiated-allogeneic-human-lung-cancer-cells-expressing-ox40l-ig-vaccine-hs-130/"
}