anti-OX40 agonist monoclonal antibody HFB301001

{
  "id": "MLC-T-ONC-010940",
  "term": "anti-OX40 agonist monoclonal antibody HFB301001",
  "field": "Oncology and biomedicine",
  "definition": "An agonistic human immunoglobulin G1 (IgG1) monoclonal antibody that recognizes the co-stimulatory receptor OX40 (CD134; tumor necrosis factor receptor superfamily member 4; TNFRSF4), with potential immunomodulatory and antineoplastic activities. Upon administration, anti-OX40 agonist monoclonal antibody HFB301001 selectively targets and binds to a unique epitope on OX40, and activates OX40 without competing with the endogenous OX40 ligand (OX40L; tumor necrosis factor ligand superfamily member 4; TNFSF4). This may induce the proliferation of memory and effector T lymphocytes and inhibit the function of T-regulatory cells (Tregs) in the tumor microenvironment (TME), thereby enhancing anti-tumor immune responses and preventing Tregs-mediated immune suppression. OX40, a cell surface glycoprotein and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on T lymphocytes and plays an essential role in T-cell activation and differentiation. HFB301001 does not lead to a downregulation of OX40 following the co-stimulation of T cells.",
  "synonyms": [
    "agonistic anti-OX40 monoclonal antibody HFB301001"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-ox40-agonist-monoclonal-antibody-hfb301001/"
}