anti-OX40 agonist monoclonal antibody GEN1055

{
  "id": "MLC-T-ONC-010939",
  "term": "anti-OX40 agonist monoclonal antibody GEN1055",
  "field": "Oncology and biomedicine",
  "definition": "An agonistic, hexabody-based monoclonal antibody that recognizes the co-stimulatory receptor OX40 (CD134; tumor necrosis factor receptor superfamily member 4; TNFRSF4), with potential immunostimulatory and antineoplastic activities. Upon administration, anti-OX40 agonist monoclonal antibody GEN1055 selectively targets and binds to OX40, thereby forming a hexamer and inducing OX40 clustering. This activates OX40 and induces the proliferation of memory and effector T lymphocytes and inhibits the function of T-regulatory cells (Tregs) in the tumor microenvironment (TME). This enhances anti-tumor immune responses and prevents Tregs-mediated immune suppression. OX40, a cell surface glycoprotein and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on T lymphocytes and plays an essential role in T-cell activation and differentiation.",
  "synonyms": [
    "agonistic anti-OX40 monoclonal antibody GEN1055"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-ox40-agonist-monoclonal-antibody-gen1055/"
}