ivuxolimab

{
  "id": "MLC-T-ONC-014606",
  "term": "ivuxolimab",
  "field": "Oncology and biomedicine",
  "definition": "An agonistic antibody that recognizes the co-stimulatory receptor OX40 (CD134; TNFRSF4), with potential immunostimulatory activity. Upon administration, ivuxolimab selectively binds to and activates OX40; which induces proliferation of memory and effector T lymphocytes. In the presence of tumor-associated antigens (TAAs), this may promote a T-cell-mediated immune response against TAA-expressing tumor cells. OX40, a cell surface glycoprotein and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on T lymphocytes and plays an essential role in T-cell activation.",
  "synonyms": [
    "PF04518600",
    "anti-OX40 agonist monoclonal antibody PF-04518600"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/ivuxolimab/"
}