autologous HPV16 E7-specific HLA-A*02:01-restricted TCR gene engineered lymphocytes KITE-439

{
  "id": "MLC-T-ONC-011650",
  "term": "autologous HPV16 E7-specific HLA-A*02:01-restricted TCR gene engineered lymphocytes KITE-439",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been genetically modified to express a T-cell receptor (TCR) specific for the human leukocyte antigen (HLA)-A*02:01-restricted human papillomavirus type 16 isoform E7 protein (HPV16 E7) with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo and re-introduction into the patient, the autologous HPV16 E7-specific HLA-A*02:01-restricted T lymphocytes KITE-439 target and bind HPV16 E7-expressing tumor cells. This may lead to cytotoxic T-lymphocyte (CTL)-mediated elimination of tumor cells expressing the HPV16 E7 antigen. HPV16 E7, a cell surface glycoprotein and tumor-associated antigen (TAA), is overexpressed in various HPV-mediated cancers.",
  "synonyms": [
    "HPV16 E7-specific HLA-A*02:01-restricted TCR gene engineered autologous T lymphocytes KITE-439",
    "HPV16 E7 T-cell receptor engineered T cells KITE-439"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-hpv16-e7-specific-hla-a-02-01-restricted-tcr-gene-engineered-kite-439/"
}