anti-HPV16 TCR-engineered T cells CRTE7A2-01

{
  "id": "MLC-T-ONC-010798",
  "term": "anti-HPV16 TCR-engineered T cells CRTE7A2-01",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of T lymphocytes that has been genetically modified to express a T-cell receptor (TCR) specific for an as of yet not identified viral oncoprotein(s) of human papillomavirus type 16 (HPV16), with potential antineoplastic activity. Upon intravenous administration, the anti-HPV16 TCR-engineered T cells CRTE7A2-01 specifically recognize and bind to the HPV16 oncoprotein(s) expressed on tumor cells. This may lead to cytotoxic T-lymphocyte (CTL)-mediated elimination of tumor cells expressing the HPV16 oncoprotein(s).",
  "synonyms": [
    "anti-HPV16 TCR T cells CRTE7A2-01",
    "anti-HPV16 TCR-T cells CRTE7A2-01"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-hpv16-tcr-engineered-t-cells-crte7a2-01/"
}