autologous TCR-engineered T cells IMA201

{
  "id": "MLC-T-ONC-011770",
  "term": "autologous TCR-engineered T cells IMA201",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that are genetically modified with a lentiviral vector encoding a T-cell receptor (TCR) specific for an as of yet not identified tumor-associated antigen (TAA), with potential antineoplastic activity. Upon intravenous administration back into the patient, the autologous TCR-engineered T cells IMA201 specifically recognize and bind to the TAA on cancer cells, which induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against the TAA-positive cancer cells.",
  "synonyms": [
    "IMA201 T cells",
    "IMA201 autologous T lymphocytes",
    "ACTengine IMA201",
    "autologous T-cell receptor-engineered T cells IMA201"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-tcr-engineered-t-cells-ima201/"
}