allogeneic anti-HA-1 TCR-engineered T cells TSC-100

{
  "id": "MLC-T-ONC-009831",
  "term": "allogeneic anti-HA-1 TCR-engineered T cells TSC-100",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of donor-derived T lymphocytes that have been genetically engineered to express a T-cell receptor (TCR) specific for HLA-A*02:01-restricted minor histocompatibility antigen HA-1 (HA1), with potential immunomodulating and antineoplastic activities. Following allogeneic haploidentical hematopoietic cell transplantation (HCT) in HLA-A*02:01 positive patients, allogeneic anti-HA-1 TCR-engineered T cells TSC-100 specifically recognize and bind to HA-1 expressed on tumor cells. This may lead to cytotoxic T-lymphocyte (CTL)-mediated elimination of tumor cells expressing HA-1. HA-1 is a lineage-specific antigen found on leukemia cells.",
  "synonyms": [
    "allogeneic T-cell receptor-engineered T cells TSC-100",
    "HA-1-targeting TCR-T cells TSC-100",
    "T-cell receptor engineered donor T cells TSC-100"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-anti-ha-1-tcr-engineered-t-cells-tsc-100/"
}