HPV-16 E7 TCR expressing T cells

{
  "id": "MLC-T-ONC-014188",
  "term": "HPV-16 E7 TCR expressing T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of allogeneic, genetically engineered T lymphocytes transduced with a retroviral vector MSGV1 that encodes a T-cell receptor (TCR) targeting a specific epitope of the human papillomavirus (HPV) type 16 oncoprotein E7 (HPV-16 E7 TCR), with potential antineoplastic activity. The TCR especially recognizes and binds with high affinity to the HPV 16 E7 11-19 epitope. Upon administration, HPV-16 E7 expressing T cells target and bind to tumor cells expressing the HPV-16 E7 antigen leading to selective cytotoxicity in HLA-A2-positive, HPV-16 E7-expressing tumor cells. HPV16 E7, a tumor-associated antigen (TAA), overexpressed in a variety of tumor cell types while not expressed in normal, healthy cells, plays a key role in tumor cell proliferation. E7 11-19 is a naturally processed epitope of HPV-16 E7 that binds specifically to human leukocyte antigen (HLA)-A*02:01 and that has been isolated from the surface of HPV-16 positive, HLA-A*02:01-positive tumor cells.",
  "synonyms": [
    "human papillomavirus type 16 E7 TCR expressing T cells",
    "HPV-16 E7 TCR-expressing T lymphocytes",
    "HPV-16 E7 TCR expressing T lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/hpv-16-e7-tcr-expressing-t-cells/"
}