liposomal HPV-16 E6/E7 multipeptide vaccine PDS0101

{
  "id": "MLC-T-ONC-014822",
  "term": "liposomal HPV-16 E6/E7 multipeptide vaccine PDS0101",
  "field": "Oncology and biomedicine",
  "definition": "A liposomal nanoparticle-based therapeutic vaccine composed of the cationic lipid R-DOTAP (R-enantiomer of 1,2-dioleoyl-3-trimethylammonium-propane chloride) encapsulating six human papillomavirus 16 (HPV-16) E6 and E7 peptides, with potential immunostimulating activity. Upon subcutaneous administration of the liposomal HPV-16 E6 and E7 multipeptide vaccine, the nanoparticles are taken up by antigen presenting cells (APCs), specifically dendritic cells (DCs), which may stimulate the immune system to induce a cytotoxic T-lymphocyte response (CTL) against HPV-16 E6 and E7-expressing tumor cells. HPV-16 E6 and E7 are oncoproteins that play a key role in the tumorigenesis of a variety of cancers.",
  "synonyms": [
    "immunoMAPK-RDOTAP /HPV-16 E6/E7 peptide antigen vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/liposomal-hpv-16-e6-e7-multipeptide-vaccine-pds0101/"
}