HPV types 16/18 E6/E7-adenoviral transduced autologous lymphocytes/alpha-galactosylceramide vaccine BVAC-C

{
  "id": "MLC-T-ONC-014186",
  "term": "HPV types 16/18 E6/E7-adenoviral transduced autologous lymphocytes/alpha-galactosylceramide vaccine BVAC-C",
  "field": "Oncology and biomedicine",
  "definition": "An immunotherapeutic vaccine composed of the immunoadjuvant alpha-galactosylceramide (a-GC) and autologous antigen presenting cells (APCs), specifically B lymphocytes and monocytes transfected with an adenoviral vector that expresses the tumor-associated antigens (TAAs) E6 and E7 derived from human papillomavirus (HPV) types 16 and 18 (HPV-16/18 E6/E7), with potential immunostimulating and antineoplastic activities. Upon administration of BVAC-C, the APCs stimulate the immune system to mount a TAA-specific cytotoxic T-lymphocyte (CTL) response, as well as natural killer (NK) cell, NK T-cell (NKT), helper T-cell and antibody-mediated immune responses, against the tumor cells. This directly or indirectly kills the TAA-expressing tumor cells. HPV-16/18 E6/E7 are overexpressed on certain tumor cell types and play key roles in tumor cell proliferation. a-GC, an NKT cell ligand, is used to specifically stimulate NKT cells and to further stimulate an anti-tumor immune response.",
  "synonyms": [
    "autologous lymphocyte/Tumor antigen gene vaccine BVAC-C"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/hpv-types-16-18-e6-e7-adenoviral-transduced-autologous-lymphocytes-alpha-vaccine/"
}