HPV 16 E7 antigen-expressing Lactobacillis casei vaccine BLS-ILB-E710c

{
  "id": "MLC-T-ONC-014175",
  "term": "HPV 16 E7 antigen-expressing Lactobacillis casei vaccine BLS-ILB-E710c",
  "field": "Oncology and biomedicine",
  "definition": "An orally available Lactobacillis casei (L. casei)-based vaccine expressing the human papillomavirus (HPV) type 16 isoform E7 protein linked to the poly-gamma-glutamate synthetase complex gene PgsA, with potential immunostimulating activity. Upon oral administration, the expressed HPV 16 E7 may stimulate the immune system to mount a mucosal cytotoxic T-lymphocyte (CTL) response against HPV 16 E7-expressing tumor cells. The poly-glutamic acid synthetase PgsA from Bacillus subtilis acts as an anchoring motif that facilitates the expression of the HPV antigen protein on the surface of the bacteria. HPV 16 E7, a cell surface glycoprotein and tumor associated antigen, is overexpressed in various viral-related cancers.",
  "synonyms": [
    "L. casei-E7 BLS_ILB_E710c",
    "LacE7 vaccine",
    "L.casei-PgsA-E7"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/hpv-16-e7-antigen-expressing-lactobacillis-casei-vaccine-bls-ilb-e710c/"
}