Modified influenza virus expressing HPV16 E6/E7 FluBHPVE6E7

{
  "id": "MLC-T-ONC-015224",
  "term": "Modified influenza virus expressing HPV16 E6/E7 FluBHPVE6E7",
  "field": "Oncology and biomedicine",
  "definition": "A cancer vaccine comprised of a modified influenza viral vector that lacks the C-terminal part of the non-structural gene NS1 (delNS) encoding the tumor-associated antigens (TAAs) human papillomavirus type 16 (HPV16) E6 and E7, with potential immunostimulating and antineoplastic activities. Upon administration, modified influenza virus expressing HPV16 E6/E7 FluBHPVE6E7 stimulates the host immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing HPV16 E6 and E7, resulting in tumor cell lysis. HPV16 E6 and E7 are oncoproteins that play a key role in the tumorigenesis of a variety of cancers.",
  "synonyms": [
    "FluBHPVE6E7",
    "delNS influenza virus expressing HPV16 E6/E7 FluBHPVE6E7"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/modified-influenza-virus-expressing-hpv16-e6-e7-flubhpve6e7/"
}