autologous NY-ESO-1-melanoma-specific CD8+ T lymphocytes

{
  "id": "MLC-T-ONC-011725",
  "term": "autologous NY-ESO-1-melanoma-specific CD8+ T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous CD8+ (cytotoxic) T lymphocytes sensitized to cancer-testis antigen NY-ESO-1 antigen with potential immunostimulating and antineoplastic activities. Autologous CD8+ T lymphocytes, isolated from a melanoma patient, are exposed to an NY-ESO-1 peptide ex vivo, expanded, and reintroduced into the patient; these tumor-reactive T-cells may stimulate a host immune response against tumor cells expressing the NY-ESO-1 antigen, resulting in tumor cell lysis. NY-ESO-1, an antigen found in normal testis, may be upregulated in various cancers, including bladder, breast, hepatocellular, melanoma, and prostate cancers.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-ny-eso-1-melanoma-specific-cd8-plus-t-lymphocytes/"
}