CHP-NY-ESO-1 peptide vaccine IMF-001

{
  "id": "MLC-T-ONC-012585",
  "term": "CHP-NY-ESO-1 peptide vaccine IMF-001",
  "field": "Oncology and biomedicine",
  "definition": "A peptide cancer vaccine containing nanoparticles of cholesteryl hydrophobized pullulan (CHP) complexed with the cancer-testis antigen NY-ESO-1 protein, with potential immunostimulating and antineoplastic activities. Upon administration, CHP-NY-ESO-1 peptide vaccine IMF-001 may stimulate the host immune system to mount a humoral and cytotoxic T-cell response against tumor cells expressing NY-ESO-1 antigen, resulting in tumor cell lysis. The self-aggregating CHP, composed of a pullulan backbone and cholesterol branches, forms stable colloidal nanoparticles in water. NY-ESO-1, an antigen found in normal testis, is upregulated in various cancers, including bladder, breast, hepatocellular, melanoma, and prostate cancers.",
  "synonyms": [
    "cholesteryl pullulan-NY-ESO-1 vaccine IMF-001"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/chp-ny-eso-1-peptide-vaccine-imf-001/"
}