autologous AFP-specific T cell receptor T cells C-TCR055

{
  "id": "MLC-T-ONC-011319",
  "term": "autologous AFP-specific T cell receptor T cells C-TCR055",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of human autologous T lymphocytes transduced with a lentiviral vector encoding for a T-cell receptor (TCR) recognizing the human leukocyte antigen (HLA)-A*02:01 restricted human alpha-fetoprotein (AFP) 158-166 peptide (FMNKFIYEI), with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the AFP specific TCR transduced T cells recognize and bind to AFP antigen-positive cells, which results in lysis and killing of AFP-positive cancer cells. AFP is overexpressed in a variety of cancers while its expression is restricted in normal tissues.",
  "synonyms": [
    "autologous AFP-specific TCR-transduced T cells C-TCR055"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-afp-specific-t-cell-receptor-t-cells-c-tcr055/"
}