autologous HBV-specific TCR-redirected T lymphocytes

{
  "id": "MLC-T-ONC-011642",
  "term": "autologous HBV-specific TCR-redirected T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of human autologous T-lymphocytes transduced with a viral vector encoding for a T cell receptor (TCR) specific for a human hepatitis B virus (HBV) surface antigen (HBsAg), with potential antineoplastic activity. Following administration, the autologous HBV antigen specific TCR-redirected autologous T lymphocytes recognize and bind to the HBV antigen-positive cells, which induces cytotoxic T-lymphocyte (CTL)-mediated elimination of HBV antigen-positive cancer cells. HBV antigens are found on HBV-positive cells and HPV-induced hepatocellular carcinoma (HCC).",
  "synonyms": [
    "autologous HBV antigen-specific TCR-redirected T cells",
    "autologous HBV/TCR-T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-hbv-specific-tcr-redirected-t-lymphocytes/"
}