Autologous dendritic cell-autologous tumor mRNA-human CD40L vaccine

{
  "id": "MLC-T-ONC-011603",
  "term": "Autologous dendritic cell-autologous tumor mRNA-human CD40L vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A cancer vaccine consisting of autologous dendritic cells transfected with autologous tumor mRNA and the human CD40 ligand (CD40L) gene with immunostimulatory and antitumor activities. Vaccination with autologous dendritic cell-autologous tumor mRNA-human CD40L vaccine may elicit a cytotoxic T cell response against tumor cells from which the autologous tumor mRNA was derived. When expressed by dendritic cells, tumor antigens and the co-stimulatory molecule CD40L, which binds to CD40 receptors on antigen presenting cells (APC), facilitate both humoral and cellular immune responses against tumor cells.",
  "synonyms": [
    "Autologous Dendritic Cell and Tumor mRNA Human CD40L Vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-dendritic-cell-autologous-tumor-mrna-human-cd40l-vaccine/"
}