CD40L-augmented autologous tumor infiltrating lymphocytes

{
  "id": "MLC-T-ONC-012407",
  "term": "CD40L-augmented autologous tumor infiltrating lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous tumor-infiltrating lymphocytes (TILs) derived from a patient's tumor that have been stimulated ex vivo with CD40 ligand (CD40L, tumor necrosis factor superfamily member 5, TNFSF5, CD154, TNF-related activation protein, TRAP, gp39) during cell expansion, with potential immunomodulating and antineoplastic activities. Upon administration, the CD40L-augmented autologous TILs specifically recognize and kill the patient's tumor cells. Stimulation with a CD40L may enhance both the expansion of the TILs and the tumor-killing ability of the TILs when returned to the patient.",
  "synonyms": [
    "CD40 ligand-stimulated autologous TILs",
    "CD40L TIL",
    "CD40L-augmented autologous TILs"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cd40l-augmented-autologous-tumor-infiltrating-lymphocytes/"
}