CBL-B inhibitor-treated autologous tumor-infiltrating lymphocytes DeTIL-0255

{
  "id": "MLC-T-ONC-012345",
  "term": "CBL-B inhibitor-treated autologous tumor-infiltrating lymphocytes DeTIL-0255",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous tumor-infiltrating lymphocytes (TILs) derived from a patient's tumor that have been treated ex vivo during cell expansion with NX-0255, an inhibitor of Casitas B-lineage lymphoma proto-oncogene-b (CBL-B), with potential immunomodulating and antineoplastic activities. Upon administration, the CBL-B inhibitor-treated autologous TILs DeTIL-0255 specifically recognize and kill the patient's tumor cells. NX-0255 enhances TIL expansion and the tumor-killing ability of the TILs when returned to the patient.",
  "synonyms": [
    "DeTIL NX-0255",
    "DeTIL NX0255",
    "autologus TILs DeTIL-0255",
    "NX-0255-treated autologous TILs DeTIL-0255",
    "NX-0255 drug-enhanced TILs"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cbl-b-inhibitor-treated-autologous-tumor-infiltrating-lymphocytes-detil-0255/"
}