Akt-1/2 inhibitor-treated tumor infiltrating lymphocytes

{
  "id": "MLC-T-ONC-009748",
  "term": "Akt-1/2 inhibitor-treated tumor infiltrating lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "Autologous tumor infiltrating lymphocytes (TILs) harvested directly from the infiltrate of a patient's tumor and treated with an inhibitor of the serine/threonine kinases Akt-1 and -2 (Akti-1/2) during ex vivo expansion, with potential antineoplastic activity. Upon reintroduction into the patient, the Akti-1/2-treated TILs recognize and kill cancer cells. Akt inhibition promotes the immunologic memory of the TILs and enhances their expansion, in vivo long-term persistence and antitumor activity.",
  "synonyms": [
    "Akti-treated TIL",
    "AKTi-treated TILs",
    "Akti-1/2-treated tumor infiltrating lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/akt-1-2-inhibitor-treated-tumor-infiltrating-lymphocytes/"
}