Ad-sig-hMUC-1/ecdCD40L vaccine

{
  "id": "MLC-T-ONC-009715",
  "term": "Ad-sig-hMUC-1/ecdCD40L vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A cancer vaccine consisting of a recombinant adenoviral vector encoding the tumor-associated antigen (TAA) human MUC-1 (hMUC-1) linked to the extracellular domain (ecd) of the co-stimulatory molecule CD40 ligand (CD40L) and an adenovirus signal sequence that encodes a secretory signal peptide (Ad-sig) with potential immunostimulating and antineoplastic activities. Due to the presence of the secretory signal peptide expressed by Ad-sig in the vaccine construct, transfected cells may secrete a fusion protein composed of hMUC-1 and the CD40L ecd. The CD40L moiety part of the fusion protein binds to CD40 receptors on dendritic cells (DCs). Subsequently, DCs may be activated and migrate, T cells may expand, and a cytotoxic T-lymphocyte (CTL) response against tumor cells that overexpress hMUC-1 may follow. MUC-1 is a hypoglycosylated TAA overexpressed by epithelial cancer cells.",
  "synonyms": [
    "Ad-sig-hMUC-1/ecdCD40L adenoviral vector vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/ad-sig-hmuc-1-ecdcd40l-vaccine/"
}