oncolytic adenovirus expressing interferon beta/CD40 ligand MEM-288

{
  "id": "MLC-T-ONC-015628",
  "term": "oncolytic adenovirus expressing interferon beta/CD40 ligand MEM-288",
  "field": "Oncology and biomedicine",
  "definition": "A conditionally replicative, oncolytic adenovirus that has been genetically engineered to encode the transgenes for the human cytokine interferon beta (IFN-beta) and MEM40, a recombinant, chimeric form of CD40 ligand (CD40L), with potential immunostimulating and antineoplastic activities. Upon intratumoral administration, the oncolytic adenovirus expressing IFN-beta/CD40L MEM-288 selectively infects and replicates in tumor cells, leading to tumor cell lysis. In addition, the IFN-beta expressed by the oncolytic adenovirus activates T lymphocytes, dendritic cells (DCs) and natural killer (NK) cells, and induces an anti-tumor immune response against the tumor cells. The CD40L expressed by the oncolytic adenovirus specifically binds to and activates CD40, a cell surface receptor that belongs to the tumor necrosis factor (TNF) receptor family and is expressed on various immune cells, such as B lymphocytes, monocytes, and DCs. Activation of CD40 induces proliferation and activation of B lymphocytes, shifts the induction of immunosuppressive macrophages towards immunostimulatory macrophages, activates monocyte-derived DCs (moDCs) and leads to the secretion of inflammatory cytokines. This activates the immune system to mount a cytotoxic T-lymphocyte (CTL) immune response against tumor cells.",
  "synonyms": [
    "oncolytic adenovirus expressing IFN-beta/CD40L MEM-288",
    "oncolytic adenovirus expressing human interferon beta and recombinant CD40 ligand MEM-288",
    "oncolytic adenovirus expressing IFN-beta/MEM40 MEM-288",
    "interferon beta/chimeric CD40 ligand-encoding adenovirus vector MEM-288",
    "IFN-beta and chimeric CD40 ligand-encoding adenovirus vector MEM-288"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/oncolytic-adenovirus-expressing-interferon-beta-cd40-ligand-mem-288/"
}