Cretostimogene grenadenorepvec

{
  "id": "MLC-T-ONC-012802",
  "term": "Cretostimogene grenadenorepvec",
  "field": "Oncology and biomedicine",
  "definition": "A recombinant oncolytic adenovirus encoding the immunohematopoietic cytokine granulocyte-macrophage colony stimulating factor (GM-CSF) with potential antineoplastic activity. Upon administration, cretostimogene grenadenorepvec selectively infects and replicates in tumor cells, which may result in tumor cells lysis. Synergistically, GM-CSF expressed by the oncolytic adenovirus may promote a cytotoxic T cell response against tumor cells harboring the oncolytic adenovirus, resulting in an immune-mediated tumor cell death.",
  "synonyms": [
    "oncolytic adenovirus encoding GM-CSF"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cretostimogene-grenadenorepvec/"
}