GM-CSF-encoding oncolytic adenovirus CGTG-102

{
  "id": "MLC-T-ONC-013993",
  "term": "GM-CSF-encoding oncolytic adenovirus CGTG-102",
  "field": "Oncology and biomedicine",
  "definition": "A recombinant, oncolytic serotype 5/3 capsid-modified adenovirus encoding the immunostimulatory cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) with potential antineoplastic activity. Upon administration, the oncolytic adenovirus selectively infects and replicates in tumor cells, which may result in tumor cell lysis. Synergistically, GM-CSF (sargramostim) expressed by the oncolytic adenovirus enhances antigen presentation, promotes natural killer (NK) cell-mediated killing and causes a cytotoxic T cell (CTL) response against tumor cells harboring the oncolytic adenovirus, resulting in an immune-mediated tumor cell death. CGTG-102 is designed to replicate only in cells with defects in the p16/Rb/E2F pathway, attributed to a mutation common in many solid tumors. Replacement of the Ad5 capsid protein knob with a knob domain from serotype 3 causes higher transduction in cancer cells as compared to normal cells.",
  "abbreviation": "Ad5/3-D24-GMCSF",
  "synonyms": [
    "ONCOS-102"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gm-csf-encoding-oncolytic-adenovirus-cgtg-102/"
}