oncolytic adenovirus expressing interferon YSCH-01

{
  "id": "MLC-T-ONC-015629",
  "term": "oncolytic adenovirus expressing interferon YSCH-01",
  "field": "Oncology and biomedicine",
  "definition": "An oncolytic adenovirus that has been genetically engineered to express interferon (IFN), with potential immunostimulating and antineoplastic activities. Upon intratumoral administration, the oncolytic adenovirus expressing IFN YSCH-01 selectively infects and replicates in tumor cells, leading to tumor cell lysis. In addition, tumor cell lysis releases a variety of tumor-associated antigens (TAAs), which may potentially result in the activation of a systemic immune response against the TAAs-expressing tumor cells. The IFN expressed by the oncolytic adenovirus also activates T-lymphocytes, dendritic cells (DCs) and natural killer (NK) cells and induces an anti-tumor immune response against the tumor cells.",
  "synonyms": [
    "oncolytic adenovirus expressing IFN YSCH-01",
    "oncolytic adenovirus YSCH-01",
    "oncolytic virus YSCH-01",
    "recombinant oncolytic adenovirus L-IFN YSCH-01"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/oncolytic-adenovirus-expressing-interferon-ysch-01/"
}