oncolytic adenovirus AdAPT-001

{
  "id": "MLC-T-ONC-015626",
  "term": "oncolytic adenovirus AdAPT-001",
  "field": "Oncology and biomedicine",
  "definition": "A replication competent human attenuated adenoviral vector, TAV-255, modified to express a human transforming growth factor beta (TGF-b) trap fusion protein that neutralizes TGF-b, with potential oncolytic, immunomodulating and antineoplastic activities. Upon administration, oncolytic adenovirus AdAPT-001 selectively binds to and replicates in tumor cells and induces tumor cell lysis. In addition, tumor cell lysis releases a variety of tumor-associated antigens (TAAs) which may potentially result in the activation of a systemic immune response against the TAAs-expresssing tumor cells. AdAPT-001 has been attenuated to prevent replication in healthy cells.",
  "synonyms": [
    "oncolytic virus AdAPT-001"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/oncolytic-adenovirus-adapt-001/"
}