oncolytic adenovirus ICOVIR5-infected autologous mesenchymal stem cells

{
  "id": "MLC-T-ONC-015631",
  "term": "oncolytic adenovirus ICOVIR5-infected autologous mesenchymal stem cells",
  "field": "Oncology and biomedicine",
  "definition": "Bone marrow-derived autologous mesenchymal stem cells (MSCs) infected with the oncolytic, replication-competent adenovirus ICOVIR5, with potential antineoplastic activity. Upon infusion of the oncolytic adenovirus ICOVIR5-infected autologous MSCs, these cells target the adenovirus to tumors. The oncolytic virus then selectively transfects and replicates in the tumor cells causing a direct cytotoxic effect and lysis of the tumor cells. In addition, the viral infection may stimulate an immune response against the virally-infected tumor cells. This may lead to an inhibition of cancer cell proliferation. ICOVIR-5, a virus derived from wild-type human adenovirus serotype 5 (Had5), has been modified to selectively replicate in tumor cells that have a deregulated retinoblastoma/E2F pathway.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/oncolytic-adenovirus-icovir5-infected-autologous-mesenchymal-stem-cells/"
}