anti-HER2/CD3 tri-specific antibody BR115

{
  "id": "MLC-T-ONC-010763",
  "term": "anti-HER2/CD3 tri-specific antibody BR115",
  "field": "Oncology and biomedicine",
  "definition": "A tri-specific T-cell engager and monoclonal antibody targeting two separate epitopes of the tumor-associated antigen (TAA) human epidermal growth factor receptor 2 (EGFR2; HER2; ErbB2) and the T-cell surface antigen CD3, with potential immunomodulating and antineoplastic activities. Upon intravenous administration, anti-HER2/CD3 tri-specific antibody BR115 targets and binds to two separate HER2 epitopes on HER2-expressing tumor cells and CD3 on T cells. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against HER2-expressing tumor cells. HER2, a receptor tyrosine kinase (RTK) mutated or overexpressed in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.",
  "synonyms": [
    "CD3/HER2/HER2 trispecific antibody BR115",
    "tri-specific T-cell engager BR115",
    "tri-specific TCE BR115",
    "anti-CD3/anti-HER2 tri-specific antibody BR115"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-her2-cd3-tri-specific-antibody-br115/"
}