EGFR tri-specific natural killer cell engager DF9001

{
  "id": "MLC-T-ONC-013270",
  "term": "EGFR tri-specific natural killer cell engager DF9001",
  "field": "Oncology and biomedicine",
  "definition": "A tri-specific natural killer (NK) cell engager targeting epidermal growth factor receptor (EGFR), with potential immunostimulating and antineoplastic activities. Upon administration, EGFR tri-specific NK cell engager DF9001 targets and binds to EGFR on tumor cells and simultaneously binds to NK cells, thereby bringing EGFR-expressing tumor cells and NK cells together. This stimulates the NK cells and results in the selective NK cell-mediated killing of EGFR-expressing tumor cells. In addition, the NK cells activate T- and B-cells, and enhance a cytotoxic T-lymphocyte (CTL)-mediated immune response against EGFR-expressing tumor cells. EGFR, overexpressed by a variety of cancers, plays a key role in tumor cell proliferation and survival.",
  "synonyms": [
    "EGFR tri-specific NK cell engager DF9001",
    "EGFR-targeting tri-specific NK cell engager DF9001",
    "TriNKET DF9001"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/egfr-tri-specific-natural-killer-cell-engager-df9001/"
}