autologous anti-MART-1 F5 T-cell receptor gene-engineered peripheral blood lymphocytes

{
  "id": "MLC-T-ONC-011469",
  "term": "autologous anti-MART-1 F5 T-cell receptor gene-engineered peripheral blood lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "Human autologous peripheral blood lymphocytes (PBLs) transduced with a melanoma antigen MART-1 epitope-determined T cell receptor (TCR) gene, with potential antineoplastic activity. PBLs are isolated from a melanoma patient and pulsed with a viral vector that encodes the TCR specific for an epitope of MART-1 (F5 TCR). After expansion ex vivo, the transduced autologous PBLs, expressing this specific TCR, are reintroduced into the patient, and bind to melanoma cells expressing the MART-1 antigen, which may result in specific cytotoxic T-lymphocyte (CTL) killing of MART-1-expressing melanoma cells. MART-1 (melanoma antigen recognized by T cells 1), also known as Melan-A, is a melanocyte lineage-specific transmembrane protein.",
  "synonyms": [
    "MSGV1AIB (anti-MART-1 TCR) retroviral vector-transduced autologous PBL"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-mart-1-f5-t-cell-receptor-gene-engineered-peripheral-blood/"
}